Physiology will undergo tremendous changes at these two points in life.

[New Sancai Compilation and First Release] Scientists from Stanford University School of Medicine in the United States have discovered that as we age, our bodies will accelerate changes in two key stages. These age-related changes occur around the ages of 44 and 60.

It's known that our bodies undergo many changes as we age, but new research published in the journal Nature Aging finds that human aging does not occur in a progressive, linear fashion. Instead, at different ages, our molecules (including RNA, proteins, and the microbiome) undergo accelerated, nonlinear changes.

According to Medical News Today, researchers analyzed data from 108 Californians aged 25 to 75, who were followed for a period ranging from 1.7 to 7 years. Participants regularly donate blood and other biological samples to help scientists track molecular changes in their bodies, examining more than 135,000 different molecules and microorganisms and obtaining approximately 250 million data points.

Michael P. Snyder, a professor of genetics at Stanford University and study author, and his team found that 81% of the changes they observed were more common in some age groups than others. The two most significant molecular and microbial differences occur in the late 40s and early 60s.

According to CNN, Snyder noted that while the changes that occur at age 60 are not surprising because many chronic diseases begin at this time due to a decline in immune system function, he is concerned about the large number of changes that occur around age 40. surprise. He did acknowledge, however, that the timing juxtaposes what many call a "midlife crisis."

In addition, the molecular changes that occur in people in their 40s are related to lifestyle factors such as alcohol, caffeine and fat metabolism, as well as cardiovascular disease and changes in skin and muscle tone. The message, the researchers suggest, is that people in their 40s should pay more attention to their alcohol and caffeine intake, as well as the amount of exercise they do, to promote health and longevity.

In individuals over 60 years of age, the greatest molecular changes were associated with cardiovascular disease, immune regulation, renal function, carbohydrate metabolism, and changes in skin and muscle. Snyder said the study points to how important it is to identify these molecular changes to help prevent aging-related diseases.

Snyder said changes in proteins that support tissue occur in both age groups, explaining changes in skin, muscle and cardiovascular function. Disease risk also rises faster after age 60.

(Compiled by: Wang Jimin)

(Editor: Jiang Qiming)

(Source of the article: Compiled and published by New Sancai)